Postdoctoral Scholar
M_MED-CORE-PULM
+1 330 356-4980
Dr. Abeydeera is a medicinal chemist, cell biologist and biomedical engineer with an interest in drug discovery and development against infectious diseases, cancers and inflammatory diseases. Dr. Abeydeera aims to identify novel drug targets to combat antimicrobial resistance, overcome resistance development in ovarian cancer, and mitigate exaggerated airway narrowing in chronic airway diseases.
His scientific approach integrates chemistry, microbiology, and immunology to address urgent clinical needs. He employs medicinal chemistry, along with in vitro, ex vivo, and in vivo disease models including transgenic mouse models and advanced microscopy to map force transmission pathways at the cellular level.
Publications
Synthesis, structural characterization, and antimicrobial activity of Zn(cloxyquin)2: towards harnessing zinc intoxication and immune response restoration to combat Staphylococcus aureus and Mycobacterium tuberculosis.
Dalton transactions (Cambridge, England : 2003)
Tax1bp1 enhances bacterial virulence and promotes inflammatory responses during Mycobacterium tuberculosis infection of alveolar macrophages.
bioRxiv : the preprint server for biology
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.
PLoS genetics
Transferrin-inspired iron delivery across the cell membrane using [(L2Fe)2(μ-O)] (L = chlorquinaldol) to harness anticancer activity of ferroptosis.
Dalton transactions (Cambridge, England : 2003)
Lipophilic Fe(III)-Complex with Potent Broad-Spectrum Anticancer Activity and Ability to Overcome Pt Resistance in A2780cis Cancer Cells.
Molecules (Basel, Switzerland)
Harnessing the Dual Antimicrobial Mechanism of Action with Fe(8-Hydroxyquinoline)3 to Develop a Topical Ointment for Mupirocin-Resistant MRSA Infections.
Antibiotics (Basel, Switzerland)
Broad-Spectrum Antimicrobial Activity of Ultrafine (BiO)2CO3 NPs Functionalized with PVP That Can Overcome the Resistance to Ciprofloxacin, AgNPs and Meropenem in Pseudomonas aeruginosa.
Antibiotics (Basel, Switzerland)
Harnessing the toxicity of dysregulated iron uptake for killing Staphylococcus aureus: reality or mirage?
Biomaterials science
An aluminum lining to the dark cloud of silver resistance: harnessing the power of potent antimicrobial activity of γ-alumina nanoparticles.
Biomaterials science
Lipophilic Ga Complex with Broad-Spectrum Antimicrobial Activity and the Ability to Overcome Gallium Resistance in both Pseudomonas aeruginosa and Staphylococcus aureus.
Journal of medicinal chemistry
Synthesis, Characterization, and BSA-Binding Studies of Novel Sulfonated Zinc-Triazine Complexes.
Bioinorganic chemistry and applications